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Footnotes Conflicts of interest There are no conflicts of interest associated with this manuscript

*Correspondence: Jixin Zhong, [email protected]

Patients notice that they are finally losing weight but they feel like theyre running on empty. That kind of fatigue is more common than most people think

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In clinical studies, liraglutide and semaglutide both led to an average 0.3-point drop in A1c in prediabetic participants (after 56 weeks for liraglutide 5 and 68 weeks for semaglutide 6 )a small but meaningful shift for people whose blood sugar is creeping upward toward the diabetes threshold