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Treatment guidelines recommend discontinuing pharmacotherapy if patients fail to achieve 5% weight loss within 3 months at maximum dosing, a criterion broadly applied across all anti-obesity drug therapies [20]

Perhaps more importantly, GIP receptor activation appears to reduce the nausea that GLP-1 agonists can cause, which helps explain why Tirzepatides tolerability surprised many researchers

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In the most recent Wegovy study, patients maintained 20% of their weight loss at four years

Abbreviations PCOS Polycystic ovary syndrome MET Metformin COM Metformin combined with semaglutide therapy CRP C-reactive protein WHR Waist-to-hip ratio UA Uric acid ALT Alanine aminotransferase AST Aspartate aminotransferase TG Triglycerides TC Total cholesterol HDL-C High-density lipoprotein cholesterol LDL-C Low-density lipoprotein cholesterol WBCs White blood cells CRP C reactive protein HbA1c Glycosylated hemoglobin FBG Fasting blood glucose FINS Fasting insulin HOMA-IR Homeostasis model assessment of insulin resistance SHBG Sex hormone binding globulin DHEA-S Dehydroepiandrosterone sulfate E2 Estradiol TEST Testosterone PRL Prolactin FAI Free androgen index LH Luteinizing hormone FSH Follicle stimulating hormone AMH Anti-Mllerian hormone CVAI Chinese visceral adiposity index hCG Human chorionic gonadotrophin CV Coefficients of variation ELISA Enzyme-linked immunosorbent assay GLP-1 RAs Glucagon-like peptide-1 receptor agonists WC Waist circumference HC Hip circumference HPO Hypothalamicpituitaryovarian SD standard deviation Author contributions Haiyan Chen and Xiaohui Lei contributed equally to this work