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Efruxifermin (formerly AKR-001, AMG 876), the only other FGF21 analog studied in a clinical trial of biopsy-confirmed NASH patients, is a 92 kDa Fc-FGF21fusion protein with a 33.5 day half-life (based on intact C-terminal domain of the FGF21 moiety), which is substantially extended relative to the FGF21 analogs described above

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The IC 50 values (mg/mL) for ASHMI, ling zhi, ku shen, and gan cao for eotaxin-1 were 38.1, 33.1, 100, and 158.5 respectively

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Near-margin adventitial (NMA) vascular dissection is equivalent to en bloc vascular resection in soft tissue sarcomas (STS)

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