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Description

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It binds to the S1P 1 receptor, which is most abundantly expressed on vascular endothelial cells, and the activation of this receptor attenuates the activity of MMPs, causing syndecan-1 ectodomain shedding (132)

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whereas in human primary pancreatic acinar cells, the IC 50 values of free Dox and Dox@vesicles were 31.00 nM and 149.30 nM

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