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We used the 3xTg mouse model of AD, which expresses familial human isoforms of APP (APPSwe), Tau(tauP301L), and Presenilin (PS1M146V), and exhibits both A and tau pathology as well as cognitive deficits 13
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Novel coupling factors Although the discussion above suggests many mitochondrial biochemical pathways produce molecules that can act as the coupling factors to amplify insulin secretion, a prominent candidate is the NADPH produced by pyruvate cycling
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Orally-swallowed B12 tablets are just as effective as injections in the vast majority of patients, except those with digestive issues that may hamper absorption
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