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4d and Extended Data Fig

77,78 The extracellular and intracellular cystine and glutamate concentrations keep the function of system Xc to protect cells in an antioxidant state

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ARNTL also inhibits the transcription of EGLN2 to repress ferroptosis, leading to the activation of HIF1A, a prosurvival transcription factor (Yang et al., 2019)