10.1007/s00424-010-0862-9 35 DuniA.LiakopoulosV.RoumeliotisS.PeschosD.DounousiE
Preclinical evidence from the Sikiric lab and collaborators describes protective effects against ethanol-induced gastric lesions, NSAID-induced enteropathy, and ileoileal anastomotic disruption in rat models, with the latter studied under the Pliva clinical-development code PL-14736 (Tkalcevi et al., 2007
it may also be of use in managing certain kinds of cancer
Phase 3 trials will provide a clearer side-effect picture
Patients were on a stable dose of metformin HCl (1500 mg per day) for at least 8 weeks prior to being randomized to one of three double-blind treatment groups to receive 5 mg dapagliflozin and 5 mg saxagliptin added to metformin, 5 mg saxagliptin and placebo added to metformin, or 5 mg dapagliflozin and placebo added to metformin
Diabetes medication review may be needed when food intake and glucose trends change