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Discontinuation Rates Treatment Discontinuation Due to Adverse Events: Retatrutide 9mg: 12.2% Retatrutide 12mg: 18.2% Placebo: 4.0% Interestingly, some discontinuations were attributed to "perceived excessive weight loss" participants felt they were losing weight too rapidly or had reached their desired weight and chose to discontinue

Sublingual semaglutide can be an incredibly supportive tool during this transition

If the primary goal is weight loss without underlying metabolic conditions, lifestyle changes like diet and exercise may be more effective in the long run

Therefore, the development of novel therapies targeting postprandial hyperglycemia, which could improve both cardiovascular outcomes and healthy life expectancy, has been sought

1 Separating Myth from Fact Myth : Anyone can take GLP-1 weight-loss drugs

doi:10.1056/NEJMoa1607141 5