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However, although the data obtained from preclinical studies involving a relatively small number of healthy subjects are promising, further comparative trials in larger populations of people with T2DM and obesity are required to confirm the therapeutic potential of this new GLP-1, GIP, and GCG receptor tri-agonist, particularly in comparison with existing selective GLP-1 and dual GLP-1/GIP receptor agonists

identified CD8 + T cells in the synovium as drivers of cartilage degeneration and subchondral bone damage through interactions with chondrocytes, offering mechanistic insight into immune-mediated OA progression (Sun et al., 2024)

Unexpected benefits for kidney and liver disease turned up in the diabetes trials, too

Bonanomi L, Gazzaniga A

Amy Sheer says shes seen some of the drawbacks of telehealth-prescribed GLP-1s in her weight management clinic at the University of Florida

arXiv link Ke, Q