Bottom line: It flips a metabolic switch to make your body better at using fat as energy and running more efficiently at the cellular level
No official contraindication exists, as both work through entirely different mechanisms and metabolic pathways
B12 is required for rapid cell division, and hair follicles are among the fastest-dividing cells in the body
Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study
Not everyone needs these treatments and thats perfectly okay
Whether a person feels more energy is not something the trials measured