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Kidney Int 2018;94:2639

Even among those who switched between GLP-1s, persistence was only 36%

Muscle loss creates a shapeless, deflated appearance

Injecting aggregated peptide delivers zero therapeutic effect and risks immune sensitization to misfolded proteins

The suspected mechanism is glucagon activity: the glucagon receptor is expressed in certain tissues of the peripheral nervous system, and its chronic activation appears to alter neurosensory signaling in some subjects

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