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PARPs: Enzymes that help repair DNA damage, but use up large amounts of NAD+ in the process

Roberts BM, Conn KM, Hildebrandt A, Connor KR, Lange E, Geddis AV, Taylor A, Ekon N, Heaton KJ, Ridgewell C, Neumeier WH (2025) The effect of transcutaneous trigeminal nerve stimulation and transcutaneous auricular vagal nerve stimulation on the biomarker response to stress

Mice were anesthetized with a combination of ketamine (100 mg/kg) and xylazine (10 mg/kg, i.p.) (Cristlia, SP, Brazil)

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Although found naturally occurring in various fruits and vegetables, to fully harness the benefits of Glutathione, the primary source of 100% bioavailable glutathione is homemade, regulated, and produced by the body

Rational combinations with other neuroprotective agents could yield synergistic effects