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For example, the Look Action for Health in Diabetes trial, which was conducted to investigate the effects of lifestyle interventions on the rates of heart disease, stroke, and CV-related deaths in obese patients, found that weight loss had little to no effect on CV events, rendering it obsolete
[DOI] [PubMed] [Google Scholar] Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt BR, Sutherland JE, Hutabarat RM, Clausen VA, Karsten V, Cehelsky J, Nochur SV, Kotelianski V, Horton J, Mant T, Chiesa J, Ritter J, Munisamy M, Vaishnaw AK, Gollob JA, Simon A, 2014
Animal model metabolomics studies reveal that HFD-induced NAFLD is characterized by hepatic saturated fatty acid (myristic acid, palmitic acid) and monounsaturated fatty acid (oleic acid) accumulation, accompanied by decreased gluconeogenic amino acid (glycine, alanine, aspartic acid, glutamic acid, proline) levels (95)
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