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Improvements: Delivery times can be less predictable

Heres what the trials actually showed, in plain English, with the figures checked against Eli Lillys own releases and The Lancet

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Patients with T2DM experience a significant decline in the incretins functional properties which causes delayed and reduced insulin release after glucose administration and impairs glucose tolerance [12,13,14]

In the meantime, some patients on long half-life GLPs are already stretching injections to every 1014 days , especially during maintenance phases

Metformin primarily reduces glucose production in the liver, while GLP-1s have broader effects on appetite, gastric emptying, and insulin/glucagon balance