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Dysesthesia Across Trials TRIUMPH-4 revealed dysesthesia (tingling, burning, or numbness) in 20.9% of participants at 12mg (8.8% at 9mg), versus 0.7% placebo

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They can occur simultaneously, but they are different

Going from 2 mg directly to 8 mg, or from 4 mg to 12 mg, dramatically increases the risk of severe gastrointestinal events and potential complications