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Enzyme-responsive drug delivery system has been demonstrated, which consist of triblock N-(2-hydroxypropyl methyl) acrylamide (HPMA) conjugated with tetrapeptide linker, which allows the high molecular weight (92 kDa) to degrade into low molecular weight (44 kDa) and deliver the paclitaxel drug at tumor site [54]
One concern is that, if pre-cancerous cells are already present, very high availability of growth-supporting nutrients such as B12 could, in theory, support their growth too
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bioRxiv , 2022.2010.2031.514523, (2022)
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