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Transepithelial chloride secretion, promoting cyst enlargement in ADPKD, can be inhibited by GSH, CoQ10 and Fer-1, which reduce TMEM16A activation, subsequently diminishing cell proliferation and fluid secretion [174]

Understanding the different types of 5-alpha reductase helps explain why localized inhibition matters

2.1.2 Informed consent statement Written informed consent was obtained from parents or legal guardians and children provided verbal assent before participation in the study

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