Diabetes 70 , 25452553 (2021)
6 Blood sugar and insulin sensitivity Human trials demonstrate that berberine can lower blood sugar and improve insulin sensitivity in people with type 2 diabetes, with effects comparable to conventional oral medications
In animal studies, administration of dexamethasone caused a reduction of GLP-1 secretion from the intestinal L cells [80] and also decreased the circulating levels of this peptide, which led to glucose intolerance and peripheral insulin resistance in rats [81]
Patients should also contact their healthcare provider if they experience severe or persistent gastrointestinal symptoms (nausea, vomiting, diarrhea) that interfere with taking other essential medications
All randomised patients completed the 12-week duration of the trial and drug compliance was full
Dosage adjustments can effectively minimize this in most clients