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In December 2014, they published a paper in Nature Medicine, showing that the triple agonists weight loss effects in mice exceeded those of the dual agonists

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Slower transit may also prolong nutrient contact with distal L-cells, potentially amplifying the secretion of beneficial hormones like GLP-1, which enhances insulin secretion and further suppresses appetite (98, 99)

The study results will be submitted for publication in a peer-reviewed journal, with findings expected in 2026

Patent number: US10278961B2, CN108997332B, US20230138576A1