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For example, the overexpression of Cu/Zn SOD was able to rescue dopaminergic neurons and diminishes locomotor disabilities in a mutant model for -synuclein overexpression [112]

Olaparib, for instance, is an FDA-approved inhibitor of the enzyme poly ADP ribose polymerase (PARP) which can efficiently kill BRCA mutant tumor cells, a successful synthetic lethality based targeting strategy used in breast cancers and ovarian cancers (165)

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