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In the United Kingdom, they are approved for weight management when combined with a reduced calorie diet and physical activity for people with obesity or for those who are overweight with related health issues
That subtle shift is what separates GLP-1 weight loss from traditional approaches
Among the plethora of novel agents against diabetes, GLP-1RAs are known to exert various biological effects in extra-pancreatic tissues beyond controlling hyperglycemia ( via central mechanisms ( Similarly, SGLT-2is, also referred to as gliflozins, represent another class of anti-hyperglycemic agents currently used in T2D treatment with favorable effects on body weight
The phase 2 trial reported that GI events were the most common adverse effects across all dose groups, and they were dose-dependent, meaning they increased in frequency and severity as the dose went up
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