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In the case of water-soluble vitamins like B12, vitamin C, folic acid, and other B vitamins, some medically reviewed literature points to early morning as the optimal time to take them as they can be taken on an empty stomach, but more peer-reviewed research is needed to confirm this claim
In one study of 1,111 people living with type 2 diabetes, 22.2 percent developed a vitamin B12 deficiency after taking metformin for at least six months
Mild adverse events were similar between treatment and placebo groups, including headache, fatigue, and gastrointestinal symptoms
doi: 10.1007/s00125-011-2205-6
Deficiency can lead to serious issues, affecting both men and women
