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Analysis of several proinflammatory cytokines, including IL-1, IL-6, TNF-, and IFN-, also revealed no significant differences between treatment groups (Supplementary Fig

After three months of intragastric Dihexa administration (1.44 or 2.88 mg/kg), the APP/PS1 mice showed restored Morris water maze performance, increased neuronal cell counts and synaptophysin expression on Nissl staining, reduced microglial and astrocyte activation, decreased pro-inflammatory cytokines (IL-1, TNF-) and increased anti-inflammatory IL-10

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Safety and Side Effects L-carnitine is generally considered a safe supplement for dogs , but, as with any supplement, side effects can occur

Obrador, E., & Estrela, J

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