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Senescent mitochondria not only produce more ROS due to inefficient electron transport but also exhibit impaired iron-sulfur cluster biogenesis, leading to improper iron handling and accumulation within the mitochondria, thus creating a potent internal source of oxidative stress (106,107)

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Br J Pharmacol (2022) 179(4):65976

B12 absorption requires intrinsic factor, a glycoprotein produced by parietal cells in the stomach lining

Pharmacokinetic parameters for rosuvastatin were unchanged by co-administration of SNAC alone