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modest heart rate increases were also observed

doi: 10.1371/journal.pone.0105478 193 NewellM

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The upsurge of very-low-density lipoprotein particles seems to be the core atherogenic dyslipidemia in T2DM, which is partially secondary to insulin resistance [26]

Drug Interactions In Vitro Assessment of Drug Interactions: Sitagliptin is not an inhibitor of CYP isozymes CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 or 2B6, and is not an inducer of CYP3A4