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An unexpected finding of Chen et al.'s study was that G6PD knock-out animals have impaired folate metabolism since methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylenetetrahydrofolate to 5-methyl-tetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine [125]

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[DOI] [PubMed] [Google Scholar] 72.Tosatto S.C.E., Bosello V., Fogolari F., Mauri P., Roveri A., Toppo S., Floh L., Ursini F., Maiorino M