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The nausea associated with semaglutide is thought to result from both its effects on gastric emptying and its action on central nervous system centers involved in nausea and appetite regulation

USA 102 , 1219412199 (2005)

Upon oxidative stress, sudden MPT causes massive ion influx that dissipates mitochondrial membrane potential and shuts down OXPHOS, ATP production and ROS overgeneration

2019;19(6):e37

While growth hormone (GH) and serum insulin-like growth factor-1 (IGF-1) are used as parameters of control and efficacy of treatment in GHD and acromegaly, glycosylated hemoglobin (HbA1c) levels are used in T1DM [1-4]

+-More strikingly, the findings suggest that GPX4 plays a crucial role in preserving intestinal homeostasis by protecting against lipid peroxidation, as evidenced by the increased vulnerability of IEC Gpx4 mice to DSS-induced colonic inflammation relative to their wild-type counterparts (65)