These include very long term effects beyond ten years, outcomes in younger populations who may use GLP-1s for decades, effects on bone health in older adults, and rare side effects that may only appear with widespread use over time
Exploration of the potential association between GLP-1 receptor agonists and suicidal or self-injurious behaviors: a pharmacovigilance study based on the FDA Adverse Event Reporting System database
Two studies also showed concomitant improvements in cognitive measures of recognition and working memory 122 and depressive-like behavior in rats administered antipsychotics 127
The standout feature is their weight loss guarantee: at least 10% body weight loss within nine months for eligible new users, or you get a full refund
Fewer Side Effects Many people stop GLP-1s early due to nausea, reflux, constipation, or fatigue
It makes a lot of sense due to the difference in response and tolerance rates among people who are taking GLP-1 medications