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PLoS One 18 , e0282063 (2023)

A randomized trial of glutamine and antioxidants in critically Ill patients

Acromegaly is an endocrine condition, which is manifested with excess secretion of pituitary GH accompanied by an elevated level of circulatory IGF-1 (273)

NADPH is also important for the antioxidant defenses of the body, so PPP is well developed in cells that are exposed to high oxygen levels such as the cornea of the eye, where PPP accounts for 60% of glucose oxidation, and in red blood cells

During brain damage (including diseases, brain injury and oxidative stress), these astrocytic functions become transiently or permanently impaired, and the subsequent impact on neuronal cells may lead to pathological conditions and neurodegenerative diseases [3,26]

Although injectable drug delivery bypasses the gastrointestinal tract, it remains associated with pain, infection risks, and reduced patient compliance