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Increased incidence or severity of renal pelvic dilatation was observed in 21 day-old pup offspring of treated dams at 75 mg/kg/day (maternal and pup dapagliflozin exposures were 1415-times and 137-times, respectively, the human values at the 10 mg clinical dose, based on AUC)

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Metabolic Rate Preservation: Prevents the metabolic slowdown usually seen during caloric deficits via thermogenesis

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The SURMOUNT-4 trial, which tested the maximum tolerated dose approach, showed a mean weight loss of 26% to 26.6% at the highest doses participants could tolerate