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It is important to note that whilst NAC shows promise in laboratory and animal studies, there is no MHRA or NICE endorsement for its use specifically in treating fatty liver disease

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However, ASS1 is frequently downregulated in fibrotic lung tissues, which promotes fibroblast activation through STAT3 signaling and drives an aggressive, apoptosis-resistant phenotype [87, 88]

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Shah S, Kellman P, Greiser A, Weale P, Zuehlsdorff S, Jerecic R