However, the findings of the SURMOUNT-1 clinical trial from 2022 saw significant weight loss when compared to placebo
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The honest caveat: Phase 2 results frequently dont fully replicate in Phase 3 with larger and more heterogeneous populations
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Inactive state stabilized by the ECD and ECL1/3 In the GLP-1RFab7F38 structure, the saddle-like ECD loop S116-E127 covers the ECL1 helical region Q211-S219 that partially occupies the orthosteric ECD-binding site (Fig