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Choline availability may also regulate and support the expression of the machinery necessary for its processing and signaling, as dietary choline supplementation increases the expression of choline receptor SLC4A7 , choline dehydrogenase ( CHDH ), choline kinase alpha ( CHKA ), choline acetyltransferase ( CHAT ), and genes related to acetylcholine (ACh)-dependent signaling such as the muscarinic ( CHRM1 and CHRM5 ) and nicotinic ( CHRNA7 ) ACh receptors (82) ( Figure 3 )

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Qualitative sex differences in pain processing: emerging evidence of a biased literature