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Daniel Drucker, MD, then a postdoctoral fellow in the Habener lab, characterized the enzymatic activity of GLP-1, while Jens Juul Holst, MD, at the University of Copehagen, simulatenously discovered GLP-1 regulated insulin secretion

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Administering degraded semaglutide may result in reduced therapeutic effect, unpredictable blood glucose control, or inadequate weight management outcomes

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Their standard reporting procedures had to be adapted to fit the trial design and clinical setting which added additional time to the study set up process