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The metanalysis includes 5,323 patients (56-61 years) with T2D inadequately controlled (HbA 1c 7-10.5%), baseline BMI 23-45 kg/m 2 , mean diabetes duration of 9-12 years, and randomized to receive a GLP-1RA or GIP/GLP-1RA versus placebo in add on to basal insulin for at least 24 weeks (24-40 weeks)

The circadian sleep connection is mechanistically coherent

As a glucagon-like peptide-1 (GLP-1) agonist, semaglutide works by mimicking an intestinal hormone that stimulates insulin release

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However, their expression in various tissues, albeit in smaller quantities, accounts for the multi-systemic effects of GLP-1RAs

GLP-1 analogues are widely used in diabetes treatments due to their mechanism of increasing insulin secretion and decreasing glucagon secretion, which in turn lowers blood sugar levels