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Most patients reach their therapeutic dose between weeks 12 and 20, though some benefit from slower escalation based on individual tolerability

When deficient, replacing it often restores appetite and energy and prevents longer-term harm

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Moreover, its triple-agonist activity produced meaningful glycemic improvements, with higher doses achieving notable reductions in HbA1c and supporting its relevance in advanced metabolic investigations

In the PIONEER trial [23], 3,183 patients were randomized to receive oral semaglutide (14.0 mg once daily) or placebo for a median period of 15.9 months

Patients in STEP trials experienced significant weight reductionsome losing 15% or more of their body weight over 68 weeks