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What they found through their research is that a population of neurons in the hindbrain [the lower part of the brain that connects it to the spinal cord] seem to play a key role in mediating the vast majority of the appetite suppressant and weight loss effects of the GLP-1 drug

doi: 10.3389/fonc.2022.1026216

Glutamine can be synthesized by cells through GLUL / glutamine synthetase (GS), which catalyzes the condensation reaction between glutamate and ammonia in an ATP-dependent manner to produce glutamine

Prevalence of obesity-associated gonadal dysfunction in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis