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Re-uptake from the cleft by the excitatory amino acid transporters (EAAT) into astrocytes terminates post-synaptic receptor activation
Biochem Soc Trans 31:13431348 Tostes MH, Teixeira HC, Gattaz WF, Brandao MA, Raposo NR (2012) Altered neurotrophin, neuropeptide, cytokines and nitric oxide levels in autism
While Nrf2 and JAK2/STAT3 are indeed activated as protective responses during MIRI, the overwhelming and dynamic nature of the oxidative insult often impairs their full protective capacity or overwhelms the defense mechanisms they regulate, leading to a functional failure in restoring redox balance
It can mistakenly begin attacking healthy tissue
Exosomal lncRNA TUG1 derived from human urine-derived stem cells attenuates renal ischemia/reperfusion injury by interacting with SRSF1 to regulate ASCL4-mediated ferroptosis
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