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In good agreement with the above-described processes, carnitine seems to be involved also in insulin sensitivity (Figure 1): it was observed that the muscle accumulation of fatty acyl-CoA derivatives or acyl metabolites inhibits both insulin signaling and glucose oxidation (Pietrocola et al., 2015

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These include nausea, diarrhoea, abdominal pain, and metallic taste, affecting up to 30% of patients, particularly when treatment is initiated or doses increased

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