Acting as a GLP-1 receptor agonist, GLP-1 binds to these receptors, increasing insulin secretion
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doi: 10.1038/nrgastro.2016.181
This is why many patients who plateau on GLP-1 therapy experience renewed progress when switching to tirzepatide-based protocols
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The benefits are genuine, but they flow through the vasculature, the nervous system, and secondary mediators more than through the organs working cells, a distinction that matters when designing drugs meant to target these tissues