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207,208,209 And GLP-1s action in the brain reduces appetite and may influence energy expenditure
The differential insulinotropic potency and other physiological effects of GIP and GLP-1 in both healthy individuals and those with T2DM may be linked to their distinct receptors and the downstream G proteins that transmit signals intracellularly
Of these, two studies ( N = 16 and N = 46, respectively) observed a positive association between the use of exenatide, liraglutide or dulaglutide and weight loss as well as HbA1c at 16 weeks 149 and 1 year 150 , while for the smaller one ( N = 7) this association was not significant 148
3 Pre-clinical studies revealed increased insulin levels in primates
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