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The patients who will do best on these medications over the long term are those who use them within a framework that protects lean mass, supports metabolic health, and addresses the behavioural and physiological underpinnings of weight regain

J.PlummerM

DOI 10.1016/j.xcrm.2025.102214.

Additionally, a separate Phase 2 trial in type 2 diabetes demonstrated up to 82 percent reduction in liver fat content at the 12 mg dose results not matched by any other weight loss medication

Its legacy extends into domains such as metabolic fitness, physique, and psychology

At higher doses, patients lost an average of nearly a quarter of their body weight, exceeding outcomes typically reported with current licensed treatments such as Wegovy (~15%) or Mounjaro (~20%)