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In addition, the SUSTAIN trials excluded patients with recent medication changes and comorbidities, such as heart failure and a history of pancreatitis, among others 1116,3133

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We did not have a good idea of whether these unpleasant side effects are related or necessary for the weight-loss effects. To find out, the Monell team investigated the brain circuits that link feeling full after ingesting a meal to those causing food avoidance due to feeling nauseated

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The 1998 Johansen pharmacokinetic paper characterised plasma half-life and absorption kinetics (PMID 9879640)