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This age-related decline has been a central focus of research interest
Acetaminophen-related ALF was the most common etiology Return to top The physiology of acetaminophen overdose 2 Acetaminophen Metabolism Acetaminophen is metabolized through 3 different pathways: 42% to 67% undergoes glucuronidation and is excreted in urine 26% to 36% undergoes sulfation and is excreted in urine 5% to 8% passes through the cytochrome P-450 pathway producing a potentially hepatotoxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI) In normal dosing, NAPQI is conjugated with the antioxidant, glutathione, and excreted in urine Return to top Mechanism of Action Overdose depletes the available glutathione and unbound NAPQI destroys liver cells
However, current research on the role of these metabolic pathways in ARDS is limited, and further basic and clinical research is required to gain a better understanding of their involvement in the pathogenesis of ARDS and to develop more effective treatments for patients
T., Dudley, V
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