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Finan B, Ma T, Ottaway N, et al
In small proof-of-concept phase 2 randomized controlled trials (RCTs) in patients with biopsy-confirmed MASH, liraglutide at 1.8 mg/day for 48 weeks (201), semaglutide at 0.4 mg/day for 72 weeks (202), and tirzepatide at 15 mg/week for 52 weeks (203) have been reported to achieve placebo-corrected percentages of participants meeting the criteria for resolution of MASH without worsening fibrosis by 30% (P = 0.019), 42% (P 10%) may lead to diabetes remission (237)
This is within the typical range for rapid weight loss but better than what is seen with some less sophisticated approaches
It is important that participants in a clinical trial do not stop taking retatrutide without first consulting their trial team , as this may have implications for trial integrity and individual health outcomes
Avoiding late meals and allowing time for digestion before lying down can help reduce acid reflux and heartburn
DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-B activation
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