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After 72 weeks, Zepbound users were found to achieve an average of 20% weight loss

P., Busija, L., & Downie, L

Others help movement but not biology

VEGF TGF-,

Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap