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10.1161/CIRCULATIONAHA.105.169404

Reduced activity of the GH/IGF-I axis in aging suggests this decline may contribute to altered body composition, sarcopenia, and frailty among the elderly

Advances in nutrition (Bethesda, Md.)

ERK1/2 activation upregulates collagen gene expression and promotes cell proliferation critical for fibroblast proliferation, while p38 MAPK inhibition reduces inflammatory response

It represents a strategic evolution in therapeutic development, moving beyond single-target approaches to multi-receptor agonism

The FDA-approved prescribing information notes that clinicians may consider delaying dose increases or temporarily decreasing the dose if patients experience troublesome gastrointestinal side effects