Even if these approaches are successful in many cases, there is still a subset (3%5% of patients) that progress to therapeutically refractive disease, constituting the so-called TC-related deaths due to the lack of effective treatment. In this view, some efforts are ongoing to identify personalized therapy for refractory patients and drug repositioning represents one of the potential alternatives (Xu et al., 2019)
Research on the traits of gut microbiota in T2DM patients who are either tolerant or intolerant to metformin showed that alterations in gut microbiota composition following metformin therapy play a role in drug intolerance (Daz-Perdigones et al., 2022)
A large international clinical trial, SELECT, has shown that when it comes to your heart health, the answer is yes
[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Coleman M., Blass J.P
I.NuberS.et al (2019)
4] Le ferite post-operatorie sono un altro candidato interessante