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K48-linked ubiquitination promotes proteasomal degradation, whereas K63-linked ubiquitination activates NLRP3 by recruiting binding partners, and deubiquitination by enzymes such as BRCA1/BRCA2-containing complex subunit 3 (BRCC3) and ubiquitin-specific protease 1 USP1/UAF1 or BRCC3 reverses this inhibition

Section 1833(t)(3)(F)(i) of the Act reduces that 3.3 percent by the productivity adjustment described in section 1886(b)(3)(B)(xi)(II) of the Act, which is a 0.7 percentage point for CY 2026 (which is also the productivity adjustment for FY 2026 in the FY 2026 IPPS/LTCH PPS proposed rule (90 FR 18257)) resulting in the proposed CY 2026 OPD fee schedule increase factor of 2.6 percent