High-dose biotin, also known as vitamin B7, can affect assays that use a biotin and streptavidin binding step, and the direction of the error depends on the assay format, with competitive designs prone to falsely high results and sandwich designs to falsely low ones
The no-observed-adverse-effect level (NOAEL) was established at 1.75 mg/kg for males and 7 mg/kg for females [141]
Fluids Barriers CNS 19, 81
Some traditional antifungal drugs, such as itraconazole, voriconazole, and amphotericin B, have serious toxicities (Zavrel and White, 2015)
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